Cis Bromo Benzoate is considered to be a ketoconazole intermediate that is prescribed for treatment of various fungal infections including histoplasmosis & candidiasis. It finds application in pharmaceutical industry as raw material in formulation of anti-fungal medication. This compound is highly pure in nature and has molecular formula C18H15BeCl2O4. Cis Bromo Benzoate is available at highly competitive prices in bulk amounts as demanded by our clients.
Disclosed is a process for preparing chiral compounds of formula (I) wherein: X?1 and X2 are independently F or Cl; and E is -SO2R2, wherein R2 is C1-C6 alkyl, -C6H4CH3 or -CF3; its enantiomer and racemates thereof, useful in the synthesis of tetrahydrofuran azole antifungals. Novel compounds of formula (II) or (III) wherein: X?1 and X2 are independently F or Cl; B represents -C(O)Q* or -CH2?OR'; Q* represents a chiral auxiliary group; R' represents a hydroxy protecting group; and A represents Cl, Br, I, triazolyl or imidazolyl; are also disclosed.